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x cystine/glutamate antiporter (xct)  (Abmart Inc)
90
Abmart Inc x cystine/glutamate antiporter (xct)
HOTTIP may suppress ferroptosis in OS cells. (A) PHOTTIP or pVector infected MG63 cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h and the relative cell viability was measured. PHOTTIP or pVector infected cells were treated with Erastin or RSL3 for 24 h, the levels of (B) iron, (C) lipid ROS, (D) MDA and (E) GSH were determined by commercial kits. (F-H) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. (I) The shHOTTIP or shNC infected U2OS cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h, the relative cell viability was measured. (J-M) The infected cells were treated with Erastin or RSL3 for 24 h, the levels of Iron (J), lipid ROS (K), MDA (L) and GSH (M) were determined by commercial kits; (N-P) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. *P<0.05; **P<0.01; ***P<0.001; ns: not significant. HOTTIP, HOXA transcript at the distal tip; OS, osteosarcoma; Fer-1, ferrostatin-1; ROS, reactive oxygen species; MDA, malondialdehyde; GSH, glutathione; xCT, X cystine/glutamate <t>antiporter;</t> GPX4, glutathione peroxidase 4; sh, short hairpin; NC, negative control.
X Cystine/Glutamate Antiporter (Xct), supplied by Abmart Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/x cystine/glutamate antiporter (xct)/product/Abmart Inc
Average 90 stars, based on 1 article reviews
x cystine/glutamate antiporter (xct) - by Bioz Stars, 2026-02
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cystine/glutamate antiporter (system xc-, xct/slc7a11)  (Huabio Inc)
90
Huabio Inc cystine/glutamate antiporter (system xc-, xct/slc7a11)
HOTTIP may suppress ferroptosis in OS cells. (A) PHOTTIP or pVector infected MG63 cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h and the relative cell viability was measured. PHOTTIP or pVector infected cells were treated with Erastin or RSL3 for 24 h, the levels of (B) iron, (C) lipid ROS, (D) MDA and (E) GSH were determined by commercial kits. (F-H) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. (I) The shHOTTIP or shNC infected U2OS cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h, the relative cell viability was measured. (J-M) The infected cells were treated with Erastin or RSL3 for 24 h, the levels of Iron (J), lipid ROS (K), MDA (L) and GSH (M) were determined by commercial kits; (N-P) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. *P<0.05; **P<0.01; ***P<0.001; ns: not significant. HOTTIP, HOXA transcript at the distal tip; OS, osteosarcoma; Fer-1, ferrostatin-1; ROS, reactive oxygen species; MDA, malondialdehyde; GSH, glutathione; xCT, X cystine/glutamate <t>antiporter;</t> GPX4, glutathione peroxidase 4; sh, short hairpin; NC, negative control.
Cystine/Glutamate Antiporter (System Xc , Xct/Slc7a11), supplied by Huabio Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cystine/glutamate antiporter (system xc-, xct/slc7a11)/product/Huabio Inc
Average 90 stars, based on 1 article reviews
cystine/glutamate antiporter (system xc-, xct/slc7a11) - by Bioz Stars, 2026-02
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cystine glutamate antiporter slc7a11  (Proteintech)
96
Proteintech cystine glutamate antiporter slc7a11
HOTTIP may suppress ferroptosis in OS cells. (A) PHOTTIP or pVector infected MG63 cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h and the relative cell viability was measured. PHOTTIP or pVector infected cells were treated with Erastin or RSL3 for 24 h, the levels of (B) iron, (C) lipid ROS, (D) MDA and (E) GSH were determined by commercial kits. (F-H) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. (I) The shHOTTIP or shNC infected U2OS cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h, the relative cell viability was measured. (J-M) The infected cells were treated with Erastin or RSL3 for 24 h, the levels of Iron (J), lipid ROS (K), MDA (L) and GSH (M) were determined by commercial kits; (N-P) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. *P<0.05; **P<0.01; ***P<0.001; ns: not significant. HOTTIP, HOXA transcript at the distal tip; OS, osteosarcoma; Fer-1, ferrostatin-1; ROS, reactive oxygen species; MDA, malondialdehyde; GSH, glutathione; xCT, X cystine/glutamate <t>antiporter;</t> GPX4, glutathione peroxidase 4; sh, short hairpin; NC, negative control.
Cystine Glutamate Antiporter Slc7a11, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cystine glutamate antiporter slc7a11/product/Proteintech
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cystine glutamate antiporter slc7a11 - by Bioz Stars, 2026-02
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cystine glutamate antiporter slc7a11  (Cusabio)
94
Cusabio cystine glutamate antiporter slc7a11
HOTTIP may suppress ferroptosis in OS cells. (A) PHOTTIP or pVector infected MG63 cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h and the relative cell viability was measured. PHOTTIP or pVector infected cells were treated with Erastin or RSL3 for 24 h, the levels of (B) iron, (C) lipid ROS, (D) MDA and (E) GSH were determined by commercial kits. (F-H) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. (I) The shHOTTIP or shNC infected U2OS cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h, the relative cell viability was measured. (J-M) The infected cells were treated with Erastin or RSL3 for 24 h, the levels of Iron (J), lipid ROS (K), MDA (L) and GSH (M) were determined by commercial kits; (N-P) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. *P<0.05; **P<0.01; ***P<0.001; ns: not significant. HOTTIP, HOXA transcript at the distal tip; OS, osteosarcoma; Fer-1, ferrostatin-1; ROS, reactive oxygen species; MDA, malondialdehyde; GSH, glutathione; xCT, X cystine/glutamate <t>antiporter;</t> GPX4, glutathione peroxidase 4; sh, short hairpin; NC, negative control.
Cystine Glutamate Antiporter Slc7a11, supplied by Cusabio, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cystine glutamate antiporter slc7a11/product/Cusabio
Average 94 stars, based on 1 article reviews
cystine glutamate antiporter slc7a11 - by Bioz Stars, 2026-02
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cystine/glutamate antiporter sas  (SAS institute)
90
SAS institute cystine/glutamate antiporter sas
HOTTIP may suppress ferroptosis in OS cells. (A) PHOTTIP or pVector infected MG63 cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h and the relative cell viability was measured. PHOTTIP or pVector infected cells were treated with Erastin or RSL3 for 24 h, the levels of (B) iron, (C) lipid ROS, (D) MDA and (E) GSH were determined by commercial kits. (F-H) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. (I) The shHOTTIP or shNC infected U2OS cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h, the relative cell viability was measured. (J-M) The infected cells were treated with Erastin or RSL3 for 24 h, the levels of Iron (J), lipid ROS (K), MDA (L) and GSH (M) were determined by commercial kits; (N-P) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. *P<0.05; **P<0.01; ***P<0.001; ns: not significant. HOTTIP, HOXA transcript at the distal tip; OS, osteosarcoma; Fer-1, ferrostatin-1; ROS, reactive oxygen species; MDA, malondialdehyde; GSH, glutathione; xCT, X cystine/glutamate <t>antiporter;</t> GPX4, glutathione peroxidase 4; sh, short hairpin; NC, negative control.
Cystine/Glutamate Antiporter Sas, supplied by SAS institute, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cystine/glutamate antiporter sas/product/SAS institute
Average 90 stars, based on 1 article reviews
cystine/glutamate antiporter sas - by Bioz Stars, 2026-02
90/100 stars
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anti-cystine/glutamate antiporter (xct) antibody  (Affinity Biosciences)
90
Affinity Biosciences anti-cystine/glutamate antiporter (xct) antibody
HOTTIP may suppress ferroptosis in OS cells. (A) PHOTTIP or pVector infected MG63 cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h and the relative cell viability was measured. PHOTTIP or pVector infected cells were treated with Erastin or RSL3 for 24 h, the levels of (B) iron, (C) lipid ROS, (D) MDA and (E) GSH were determined by commercial kits. (F-H) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. (I) The shHOTTIP or shNC infected U2OS cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h, the relative cell viability was measured. (J-M) The infected cells were treated with Erastin or RSL3 for 24 h, the levels of Iron (J), lipid ROS (K), MDA (L) and GSH (M) were determined by commercial kits; (N-P) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. *P<0.05; **P<0.01; ***P<0.001; ns: not significant. HOTTIP, HOXA transcript at the distal tip; OS, osteosarcoma; Fer-1, ferrostatin-1; ROS, reactive oxygen species; MDA, malondialdehyde; GSH, glutathione; xCT, X cystine/glutamate <t>antiporter;</t> GPX4, glutathione peroxidase 4; sh, short hairpin; NC, negative control.
Anti Cystine/Glutamate Antiporter (Xct) Antibody, supplied by Affinity Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/anti-cystine/glutamate antiporter (xct) antibody/product/Affinity Biosciences
Average 90 stars, based on 1 article reviews
anti-cystine/glutamate antiporter (xct) antibody - by Bioz Stars, 2026-02
90/100 stars
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cystine/glutamate antiporter (slc7a11  (Arigo Biolaboratories)
90
Arigo Biolaboratories cystine/glutamate antiporter (slc7a11
HOTTIP may suppress ferroptosis in OS cells. (A) PHOTTIP or pVector infected MG63 cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h and the relative cell viability was measured. PHOTTIP or pVector infected cells were treated with Erastin or RSL3 for 24 h, the levels of (B) iron, (C) lipid ROS, (D) MDA and (E) GSH were determined by commercial kits. (F-H) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. (I) The shHOTTIP or shNC infected U2OS cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h, the relative cell viability was measured. (J-M) The infected cells were treated with Erastin or RSL3 for 24 h, the levels of Iron (J), lipid ROS (K), MDA (L) and GSH (M) were determined by commercial kits; (N-P) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. *P<0.05; **P<0.01; ***P<0.001; ns: not significant. HOTTIP, HOXA transcript at the distal tip; OS, osteosarcoma; Fer-1, ferrostatin-1; ROS, reactive oxygen species; MDA, malondialdehyde; GSH, glutathione; xCT, X cystine/glutamate <t>antiporter;</t> GPX4, glutathione peroxidase 4; sh, short hairpin; NC, negative control.
Cystine/Glutamate Antiporter (Slc7a11, supplied by Arigo Biolaboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cystine/glutamate antiporter (slc7a11/product/Arigo Biolaboratories
Average 90 stars, based on 1 article reviews
cystine/glutamate antiporter (slc7a11 - by Bioz Stars, 2026-02
90/100 stars
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cystine/glutamate antiporter  (Hasegawa Co Ltd)
90
Hasegawa Co Ltd cystine/glutamate antiporter
HOTTIP may suppress ferroptosis in OS cells. (A) PHOTTIP or pVector infected MG63 cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h and the relative cell viability was measured. PHOTTIP or pVector infected cells were treated with Erastin or RSL3 for 24 h, the levels of (B) iron, (C) lipid ROS, (D) MDA and (E) GSH were determined by commercial kits. (F-H) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. (I) The shHOTTIP or shNC infected U2OS cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h, the relative cell viability was measured. (J-M) The infected cells were treated with Erastin or RSL3 for 24 h, the levels of Iron (J), lipid ROS (K), MDA (L) and GSH (M) were determined by commercial kits; (N-P) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. *P<0.05; **P<0.01; ***P<0.001; ns: not significant. HOTTIP, HOXA transcript at the distal tip; OS, osteosarcoma; Fer-1, ferrostatin-1; ROS, reactive oxygen species; MDA, malondialdehyde; GSH, glutathione; xCT, X cystine/glutamate <t>antiporter;</t> GPX4, glutathione peroxidase 4; sh, short hairpin; NC, negative control.
Cystine/Glutamate Antiporter, supplied by Hasegawa Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cystine/glutamate antiporter/product/Hasegawa Co Ltd
Average 90 stars, based on 1 article reviews
cystine/glutamate antiporter - by Bioz Stars, 2026-02
90/100 stars
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cystine glutamate antiporter solute carrier family 7 member 11  (Proteintech)
96
Proteintech cystine glutamate antiporter solute carrier family 7 member 11
HOTTIP may suppress ferroptosis in OS cells. (A) PHOTTIP or pVector infected MG63 cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h and the relative cell viability was measured. PHOTTIP or pVector infected cells were treated with Erastin or RSL3 for 24 h, the levels of (B) iron, (C) lipid ROS, (D) MDA and (E) GSH were determined by commercial kits. (F-H) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. (I) The shHOTTIP or shNC infected U2OS cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h, the relative cell viability was measured. (J-M) The infected cells were treated with Erastin or RSL3 for 24 h, the levels of Iron (J), lipid ROS (K), MDA (L) and GSH (M) were determined by commercial kits; (N-P) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. *P<0.05; **P<0.01; ***P<0.001; ns: not significant. HOTTIP, HOXA transcript at the distal tip; OS, osteosarcoma; Fer-1, ferrostatin-1; ROS, reactive oxygen species; MDA, malondialdehyde; GSH, glutathione; xCT, X cystine/glutamate <t>antiporter;</t> GPX4, glutathione peroxidase 4; sh, short hairpin; NC, negative control.
Cystine Glutamate Antiporter Solute Carrier Family 7 Member 11, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cystine glutamate antiporter solute carrier family 7 member 11/product/Proteintech
Average 96 stars, based on 1 article reviews
cystine glutamate antiporter solute carrier family 7 member 11 - by Bioz Stars, 2026-02
96/100 stars
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HOTTIP may suppress ferroptosis in OS cells. (A) PHOTTIP or pVector infected MG63 cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h and the relative cell viability was measured. PHOTTIP or pVector infected cells were treated with Erastin or RSL3 for 24 h, the levels of (B) iron, (C) lipid ROS, (D) MDA and (E) GSH were determined by commercial kits. (F-H) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. (I) The shHOTTIP or shNC infected U2OS cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h, the relative cell viability was measured. (J-M) The infected cells were treated with Erastin or RSL3 for 24 h, the levels of Iron (J), lipid ROS (K), MDA (L) and GSH (M) were determined by commercial kits; (N-P) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. *P<0.05; **P<0.01; ***P<0.001; ns: not significant. HOTTIP, HOXA transcript at the distal tip; OS, osteosarcoma; Fer-1, ferrostatin-1; ROS, reactive oxygen species; MDA, malondialdehyde; GSH, glutathione; xCT, X cystine/glutamate antiporter; GPX4, glutathione peroxidase 4; sh, short hairpin; NC, negative control.

Journal: Oncology Reports

Article Title: HOTTIP suppresses ferroptosis via mediating DGCR8/miR-214-3p/GPX4 regulatory axis in osteosarcoma

doi: 10.3892/or.2025.8927

Figure Lengend Snippet: HOTTIP may suppress ferroptosis in OS cells. (A) PHOTTIP or pVector infected MG63 cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h and the relative cell viability was measured. PHOTTIP or pVector infected cells were treated with Erastin or RSL3 for 24 h, the levels of (B) iron, (C) lipid ROS, (D) MDA and (E) GSH were determined by commercial kits. (F-H) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. (I) The shHOTTIP or shNC infected U2OS cells were treated with 10 µM Erastin or 1 µM RSL3 in the absence or presence of 2 µM Fer-1 for 24 h, the relative cell viability was measured. (J-M) The infected cells were treated with Erastin or RSL3 for 24 h, the levels of Iron (J), lipid ROS (K), MDA (L) and GSH (M) were determined by commercial kits; (N-P) The ferroptosis relevant proteins expressions of xCT and GPX4 were examined by western blotting. β-actin served as a loading control. *P<0.05; **P<0.01; ***P<0.001; ns: not significant. HOTTIP, HOXA transcript at the distal tip; OS, osteosarcoma; Fer-1, ferrostatin-1; ROS, reactive oxygen species; MDA, malondialdehyde; GSH, glutathione; xCT, X cystine/glutamate antiporter; GPX4, glutathione peroxidase 4; sh, short hairpin; NC, negative control.

Article Snippet: Primary antibodies, X cystine/glutamate antiporter (xCT; cat. no. T57046 ; 1:1,000; Abmart Pharmaceutical Technology Co., Ltd.), GPX4 (cat. no. T56959 ; 1:1,000; Abmart Pharmaceutical Technology Co., Ltd.), DGCR8 (cat. no. ET1609-32; 1:1,000; HuaBio), Ubiquitin (cat. no. T55965 ; 1:1,000; Abmart Pharmaceutical Technology Co., Ltd.) and β-actin (cat. no. P30002 ; 1:1,000; Abmart Pharmaceutical Technology Co., Ltd.).

Techniques: Infection, Western Blot, Control, Negative Control